Thermoregulation In Humans Pdf Files

Thermoregulation in humans pdf files

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Thermoregulation in humans pdf files

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Thermoregulation in humans pdf files

The transient receptor potential TRP family of ion channels comprises nonselective cation channels that respond to a wide range of chemical and thermal stimuli. However, TRPM8 has also been implicated in mammalian thermoregulation and antagonists have the potential to induce hypothermia in patients.


We report herein the identification and optimization of a series of TRPM8 antagonists that ultimately led to the discovery of PF The clinical finding with this compound will be discussed, including both efficacy and its ability to affect thermoregulation processes in humans. Synthetic details for all compounds described.

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Thermoregulation in humans pdf files

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Article Views Altmetric -. Citations Supporting Information. Cited By. This article is cited by 28 publications.

Thermoregulation of Human Body

Ruhul Amin, Colleen E. Hilton, Wade D. Daniel B. Bartberger, Jeffrey Clarine, Carl D. Davis, Vijay K. Kaller, Sonya G. Lehto, Qingyian Liu, Vu V. Ma, Holger Monenschein, Thomas T.

Thermoregulation in humans pdf files

Nguyen, Chester C. Yuan, Beth D.

Temperature Homeostasis (Regulation)

Journal of Medicinal Chemistry , 61 18 , DOI: Journal of Medicinal Chemistry , 61 14 , Journal of Medicinal Chemistry , 59 22 , Reiko Sakaguchi, Yasuo Mori.

Transient receptor potential TRP channels: Biosensors for redox environmental stimuli and cellular status. Free Radical Biology and Medicine , , Current Drug Targets , 20 7 , Ying Yin, Son C. Le, Allen L. Hsu, Mario J. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.

Homeostasis:- Thermoregulation - AQA GCSE Biology 9-1

Science , , eaav Kirin Gada, Leigh D Plant. British Journal of Pharmacology , 2 , Francesco De Logu, Pierangelo Geppetti. Ion Channel Pharmacology for Pain Modulation. Magdalene M Moran, Arpad Szallasi. Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field.

British Journal of Pharmacology , 12 , Borschel, Gabriel C. Lander, Seok-Yong Lee. Structure of the cold- and menthol-sensing ion channel TRPM8. Science , , Magdalene M. Annual Review of Pharmacology and Toxicology , 58 1 , Angeles Bonache, Pedro J. Scientific Reports , 7 1 DOI: Andrea R.

Thermoregulation in humans pdf files

Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach. Andy Weyer, Sonya Lehto.

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Pharmaceuticals , 10 4 , James R. A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF TRP channels in brown and white adipogenesis from human progenitors: new therapeutic targets and the caveats associated with the common antibiotic, streptomycin. Gregory R. Monteith, Natalia Prevarskaya, Sarah J. The calcium—cancer signalling nexus. Nature Reviews Cancer , 17 6 , Young S.

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Gwak, Claire E. Hulsebosch, Joong Woo Leem. Neural Plasticity , , TRP channels: potential drug target for neuropathic pain.

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Inflammopharmacology , 24 6 , Greg Dussor, Yu-Qing Cao. TRPM8 and Migraine. TRPM8: a potential target for cancer treatment. Journal of Cancer Research and Clinical Oncology , 9 , Dan M.

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McEntire, Daniel R. Kirkpatrick, Nicholas P. Dueck, Mitchell J. Kerfeld, Tyler A. Smith, Taylor J.

Background & Summary

Nelson, Mark D. Reisbig, Devendra K. Pain transduction: a pharmacologic perspective. Expert Review of Clinical Pharmacology , 9 8 , Nelson S. Matthew A. Duncton, Ryan B. Murray, Gary Park, Rajinder Singh. Tetrazolone as an acid bioisostere: application to marketed drugs containing a carboxylic acid. Ion channel therapeutics for pain.

Thermoregulation in humans pdf files

Channels , 9 6 ,